top of page
Mepro logo on Microfluidics Innovation Hub website.
Open Call Project
Sperm Selection Chip for Assisted Reproduction

Revolutionizing Assisted Reproduction with Microfluidics

In the realm of assisted reproduction, selecting the most viable sperm is crucial for increasing the chances of successful fertilization. MEPROlife s.l., through its innovative SpermSort technology, is setting a new standard in sperm selection. By integrating advanced microfluidic techniques with precise molecular diagnostics, SpermSort enhances the selection process, potentially boosting pregnancy rates significantly. This innovative project is part of the NextGenMicrofluidics (NGM) Open Call, managed by the Microfluidics Innovation Hub (MIH).

The SpermSort Technology

SpermSort is designed to enhance in-vitro fertilization (IVF) outcomes by combining physiological and biochemical selection processes. It uses a microfluidic chip functionalized with anti-CD10 antibodies to selectively capture and exclude low-viability sperm cells. These CD10-positive cells are often associated with DNA fragmentation and decreased motility. SpermSort technology ensures that only the most motile and viable sperm cells, free from DNA damage, are collected for fertilization.

Key components and features include:

  • Microfluidic Chip: A disposable device made from cyclic olefin copolymer (COC), designed to optimize sperm selection.

  • Surface Functionalization: Utilizes anti-CD10 antibodies or aptamers for capturing CD10-expressing sperm cells.

  • Dual Selection Mechanism: Combines motility-based selection with molecular diagnostics.

The goal of the SpermSort project is to improve the success rates of IVF by providing a reliable, cost-effective method for selecting the highest quality sperm. This technology not only enhances the likelihood of successful fertilization but also reduces the need for repeated treatment cycles, lowering the emotional and financial burden on couples undergoing fertility treatments.

Impactful Objectives:

  • Increase IVF Success Rates: By selecting only the most viable sperm, the chances of successful fertilization are significantly improved.

  • Reduce Treatment Costs: Optimizing manufacturing processes to make the technology more affordable and accessible.

  • Expand Market Reach: Aim for CE Mark and FDA approval to commercialize the product in Europe, the US, and Japan.

Explore the future of fertility treatment

Explore the future of fertility treatment with MEPROlife’s SpermSort technology! Contact us today to learn how our advanced microfluidic chip can enhance IVF outcomes and support couples in their journey towards parenthood.

Illustration of mepro sperm selection chip working principle.

Transition to Roll-to-Roll Manufacturing: Evaluate and implement R2R processes to reduce production costs and improve scalability.
Optimize Surface Functionalization: Shift from antibody to aptamer-based functionalization to simplify production and extend product shelf life.
Enhance Distribution Logistics: Develop solutions to transport and store the chips at room temperature, reducing distribution costs and complexity.


Manufacturing Evaluation: Investigate R2R production methods to replace current injection molding processes.
Functionalization Techniques: Explore and validate aptamer-based surface functionalization to enhance chip durability and performance.
Logistics Optimization: Adapt chip designs to allow for stable, room-temperature storage and transport.


High Precision in Sperm Selection: Ability to distinguish and exclude less viable sperm based on molecular and motility characteristics.
Durable and Reliable Chip Design: Ensuring the microfluidic chip maintains performance and integrity under various conditions.
Cost-Effective Production: Utilizing R2R manufacturing techniques to produce chips at lower costs.
Extended Shelf Life: Transition to aptamer functionalization to enable stable storage at room temperature.

The Role of the #MIHfamily

  • Biomedical Research Foundation of the Academy of Athens (BRFAA): Specializes in surface biofunctionalization and immobilization.

  • Fundacion Tecnalia Research & Innovation (TEC): Focuses on sterilization protocols and surface characterization.

  • Micronit (MIC): Provides design, bonding, and prototyping expertise for the microfluidic chips.

  • Inmold (INM): Leads the transition to roll-to-roll (R2R) manufacturing for cost-effective production.

Partners Involved

Get more Insights

Stay informed as MEPROlife and MIH continue to innovate in the field of assisted reproduction. Explore how our collaborative efforts are paving the way for enhanced fertility treatments and transforming the IVF landscape.

Services and Technologies

The #MIHfamily brings together a wealth of expertise and resources to support MEPROlife in overcoming technical challenges and achieving project goals. From biofunctionalization to advanced manufacturing techniques, the collaborative efforts of MIH and its partners are pivotal in driving the success of the SpermSort project.

bottom of page